This paper studies the technology of STM32 chip,expatiates on the working principle and implementation method of USB interface protocol,and uses the built-in chip to write the interface program to realize USB full speed (FS) communication.Through the actual test,the maximum transmission speed can reach 12Mbps.The research results have been applied in the oil platform automatic weather station,ship automatic weather station,island automatic weather station,traffic automatic weather station and so on,which could achieve data high-speed download and to be an effective backup communication system widely used in business.